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A compassionate oncologist and House's only real friend, who sees past the caustic exterior to the damaged man beneath and enables his worst habits while hoping for his best.

A former member of House's diagnostic team who's witnessed the House-Wilson dynamic for years and recognizes what's happening before House himself does.

The hospital administrator caught between her professional duty to reign in House and her complicated personal feelings, serving as both enabler and obstacle to his self-destruction.

A brilliant but deeply cynical diagnostician who uses sarcasm and Vicodin to keep the world at arm's length, hiding years of emotional pain behind intellectual superiority.